Hey Terry,
I appreciate your message, and I'm sorry to hear that you haven't seen any changes yet.
The effects of NMN and Resveratrol can vary from person to person due to differences in metabolism. Some individuals may notice its effects more quickly than others.
If you still want to give it a go, you might try increasing your dosage by 250mg at a time, up to a maximum of 1000mg. Monitor how you feel after each increase to make sure you're tolerating it well. For example, if you're currently taking 500mg for both NMN and Resveratrol daily, try taking 750mg for the next 7 days on an empty stomach and make sure you take hot drinks 30-40 minutes after NMN or Resveratrol as it can degrade both supplements.
Research suggests that most people experience the highest NAD+ production from NMN supplementation around 3-4 weeks, with benefits becoming more apparent between 8-12 weeks. Patience is key. You might find valuable insights by searching for 'long-term administration NMN.'
If you're still not experiencing the desired effects after 12 weeks, factors like the MTHFR gene mutation or sensitivity to niacin could be at play. In this case, it might be helpful to start with a lower dose and consider taking substances like TMG or B vitamins, which support methylation.
Remember, consistency is key when it comes to supplements. Taking NMN regularly with the best dosage will help you achieve the best possible results.
Please do let us know if you need help, we're happy to assist.
Cheers,
Michael